The effects of garlic supplements and exercise on the levels of Lipocalin-2 and insulin resistance among middle-aged obese women

The aim of this study was to investigate the effect concurrent exercise training at 70-80%HR with consuming garlic supplement on Lipocalin2, insulin level and insulin resistance in obese woman. For this purpose , 38 non diabetic woman that have no exercise training before last 6 month ago ,randomly put in 4 groups of control, exercise, supplement, exercise + supplement. Subjects in exercise groups have aerobic exercise (70-80%HR) and resistance exercise program for 10 weeks. Two garlic tablet daily for 10 weeks has been considered for supplement groups .Anthropometric values and blood samples has been taken before and after 10 weeks. Data were analyzed using the repeated measures of ANOVA and Paired-sample T test. Data analyses revealed that exercise has not significant effect on weight and body fat percentage. After exercise training and consuming garlic supplements, lipocalin2, insulin and insulin resistance have significant difference by t test analyze in groups. Based on the findings of the present study, exercise training and consuming garlic supplement have beneficial effect on metabolic risk factors in obese woman. KEY WORD: Lipocalin2, insulin resistance, garlic supplement, metabolic risk factors, concurrent exercise.